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Alan F Hofmann Selected Research

3beta,7beta-dihydroxy-5-cholen-24-oic acid

1/2006Chemical synthesis of the 3-sulfooxy-7-N-acetylglucosaminyl-24-amidated conjugates of 3beta,7beta-dihydroxy-5-cholen-24-oic acid, and related compounds: unusual, major metabolites of bile acid in a patient with Niemann-Pick disease type C1.

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Alan F Hofmann Research Topics

Disease

9Cholestasis
01/2016 - 01/2002
8Fibrosis (Cirrhosis)
01/2019 - 03/2003
5Diarrhea
11/2009 - 06/2003
4Type C Niemann-Pick Disease (Niemann Pick Disease, Type C)
09/2015 - 01/2006
4Gallstones (Gallstone)
08/2014 - 04/2005
3Liver Diseases (Liver Disease)
06/2014 - 06/2009
3Steatorrhea
03/2009 - 01/2003
2Constipation
01/2019 - 11/2008
2Liver Cirrhosis (Hepatic Cirrhosis)
01/2019 - 08/2014
2Niemann-Pick Diseases (Niemann Pick Disease)
09/2015 - 09/2009
2Biliary Liver Cirrhosis (Primary Biliary Cirrhosis)
08/2013 - 11/2005
2Sclerosing Cholangitis
06/2009 - 02/2006
2Ascites
11/2005 - 03/2003
1Non-alcoholic Fatty Liver Disease
01/2019
1Digestive System Diseases
09/2015
1Bacterial Infections (Bacterial Infection)
06/2014
1Liver Failure
08/2013
1Weight Loss (Weight Reduction)
08/2013
1Avitaminosis (Vitamin Deficiency)
05/2013
1Intestinal Diseases (Diseases, Intestinal)
05/2013
1Hepatitis
05/2013
1Type 2 Diabetes Mellitus (MODY)
05/2011
1Hepatocellular Carcinoma (Hepatoma)
11/2010
1Disease Progression
11/2010
1Cholangitis
11/2010
1Breast Neoplasms (Breast Cancer)
10/2010
1Irritable Bowel Syndrome (Syndrome, Irritable Bowel)
03/2009
1Colonic Neoplasms (Colon Cancer)
01/2008
1Celiac Disease (Celiac Sprue)
07/2007
1Wounds and Injuries (Trauma)
07/2007
1Drug Overdose
07/2007
1Flushing
02/2006
1Inflammation (Inflammations)
02/2006
1Drug-Related Side Effects and Adverse Reactions
11/2005
1Varicose Veins (Varicose Vein)
11/2005
1Hemorrhage
11/2005
1Brain Diseases (Brain Disorder)
11/2005
1Neoplasms (Cancer)
11/2005
1Cholelithiasis
08/2004
1Pulmonary Embolism
01/2004
1Gastrointestinal Diseases (Functional Gastrointestinal Disorders)
06/2003
1Malabsorption Syndromes (Malabsorption Syndrome)
06/2003
1Endotoxemia
03/2003

Drug/Important Bio-Agent (IBA)

26Bile Acids and Salts (Bile Acids)IBA
01/2019 - 01/2002
6Ursodeoxycholic Acid (Urso)FDA LinkGeneric
08/2013 - 11/2005
5CholesterolIBA
09/2015 - 04/2005
5AcidsIBA
10/2013 - 06/2009
3Phospholipids (Phosphatides)FDA LinkGeneric
01/2007 - 01/2003
2Carbon Tetrachloride (Tetrachloromethane)IBA
08/2014 - 06/2014
2EnzymesIBA
08/2013 - 06/2003
2LipidsIBA
05/2013 - 01/2002
2Chenodeoxycholic Acid (Chenix)FDA Link
01/2011 - 11/2008
2Taurocholic Acid (Sodium Taurocholate)IBA
11/2010 - 09/2006
2Peptides (Polypeptides)IBA
11/2010 - 09/2006
2Therapeutic UsesIBA
11/2010 - 06/2009
2Proteins (Proteins, Gene)FDA Link
10/2010 - 01/2008
224-norursodeoxycholic acidIBA
06/2009 - 02/2006
1Protons (Proton)IBA
01/2019
1Oxidoreductases (Dehydrogenase)IBA
09/2015
1NLR ProteinsIBA
06/2014
1NucleotidesIBA
06/2014
1Acetylmuramyl-Alanyl-IsoglutamineIBA
06/2014
1LigandsIBA
06/2014
1phenacyl bromideIBA
05/2014
1BuffersIBA
05/2014
1SulfatasesIBA
05/2014
12-Propanol (Isopropyl Alcohol)FDA LinkGeneric
05/2014
1choloylglycine hydrolaseIBA
05/2014
1EstersIBA
05/2014
1Biomarkers (Surrogate Marker)IBA
10/2013
1AmidesIBA
10/2013
1Glucagon-Like Peptide 1 (GLP 1)IBA
05/2011
1Adenosine Triphosphate (ATP)IBA
11/2010
1Taurolithocholic AcidIBA
11/2010
1TaurineFDA Link
11/2010
1ATP-Binding Cassette Sub-Family B Member 4IBA
11/2010
1Cholic AcidIBA
10/2010
1Member 1 Subfamily B ATP Binding Cassette TransporterIBA
10/2010
1AcridinesIBA
10/2010
1ElacridarIBA
10/2010
1Fibroblast Growth Factors (Fibroblast Growth Factor)IBA
11/2009
1Colesevelam Hydrochloride (Welchol)FDA Link
03/2009
1Deoxycholic Acid (Sodium Deoxycholate)IBA
11/2008
1Lithocholic AcidIBA
01/2008
1Dietary ProteinsIBA
07/2007
1antineoplaston A10 (A 10)IBA
07/2007
1Member 11 Subfamily B ATP Binding Cassette TransporterIBA
09/2006
13beta,7beta-dihydroxy-5-cholen-24-oic acidIBA
01/2006
1Methotrexate (Mexate)FDA LinkGeneric
11/2005
1BilirubinIBA
11/2005
1Serum AlbuminIBA
11/2005
1Fondaparinux (Arixtra)FDA Link
01/2004
1Ether (Diethyl Ether)IBA
06/2003
1cholylsarcosineIBA
03/2003

Therapy/Procedure

6Therapeutics
08/2014 - 01/2003
2Ligation
08/2014 - 06/2014
1Catheters
01/2016
1Glycemic Control
05/2011
1Transplantation
11/2005
1Liver Transplantation
11/2005